PROTECTION AGAINST DIHEMATOPORPHYRIN ETHER PHOTOSENSITIVITY
Identifieur interne : 003244 ( Main/Exploration ); précédent : 003243; suivant : 003245PROTECTION AGAINST DIHEMATOPORPHYRIN ETHER PHOTOSENSITIVITY
Auteurs : Michael J. Manyak [États-Unis] ; Paul D. Smith [États-Unis] ; Frank S. Harrington [États-Unis] ; Seth M. Steinberg [États-Unis] ; Eli Glatstein [États-Unis] ; Angelo Russo [États-Unis]Source :
- Photochemistry and Photobiology [ 0031-8655 ] ; 1988-06.
Abstract
AbstractAmelioration of dihematoporphyrin ether (DHE) induced skin photosensitivity by medications either suspected or known to influence porphyrin metabolism or inflammatory response was evaluated in 357 female athymic NCR‐nude mice (308 study animals, 49 controls) in 56 separate study groups. Seventy‐two hours after injection with 25 mg/kg of DHE, the study animals'abdomens were irradiated with 4.125‐4.25 J/cm2 of visible light. Controls were irradiated after receiving either medication, solubilizing agent, or no injection. The abdominal surface burns were examined daily and graded as extensive, partial, or no burn. Statistical comparison was made between irradiated mice injected with DHE only and irradiated mice injected with DHE and medication. Injection of medications which influenced metabolism (hydroxychloroquine, hydrochlorothiazide) produced fewer extensive (P < 0.01) but greater frequencies of partial burns than DHE controls. Medications which block histamine effect (cimetidine and/or hydroxyzine) resulted in fewer extensive (P < 0.03) and roughly equal frequencies of partial burns compared with DHE controls. Steroids (dexamethasone, methylpred‐nisolone, triamcinolone) which interfere with inflammatory response resulted in similar extensive and partial burn levels. Control animals receiving only medication, solubilizing agent, or no injection had no photosensitivity and consequently showed no burns. The results from this study suggest that inhibition of histamine effect and, to a lesser extent, increased activity of porphyrin catabolic pathways may decrease skin photosensitivity associated with DHE administration.
Url:
DOI: 10.1111/j.1751-1097.1988.tb01666.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000107
- to stream Istex, to step Curation: 000107
- to stream Istex, to step Checkpoint: 002006
- to stream Main, to step Merge: 003315
- to stream Main, to step Curation: 003244
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">PROTECTION AGAINST DIHEMATOPORPHYRIN ETHER PHOTOSENSITIVITY</title>
<author><name sortKey="Manyak, Michael J" sort="Manyak, Michael J" uniqKey="Manyak M" first="Michael J." last="Manyak">Michael J. Manyak</name>
</author>
<author><name sortKey="Smith, Paul D" sort="Smith, Paul D" uniqKey="Smith P" first="Paul D." last="Smith">Paul D. Smith</name>
</author>
<author><name sortKey="Harrington, Frank S" sort="Harrington, Frank S" uniqKey="Harrington F" first="Frank S." last="Harrington">Frank S. Harrington</name>
</author>
<author><name sortKey="Steinberg, Seth M" sort="Steinberg, Seth M" uniqKey="Steinberg S" first="Seth M." last="Steinberg">Seth M. Steinberg</name>
</author>
<author><name sortKey="Glatstein, Eli" sort="Glatstein, Eli" uniqKey="Glatstein E" first="Eli" last="Glatstein">Eli Glatstein</name>
</author>
<author><name sortKey="Russo, Angelo" sort="Russo, Angelo" uniqKey="Russo A" first="Angelo" last="Russo">Angelo Russo</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3F2B3C57C23C404530C3C9459B88A875163C0931</idno>
<date when="1988" year="1988">1988</date>
<idno type="doi">10.1111/j.1751-1097.1988.tb01666.x</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-GFL44TST-0/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000107</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000107</idno>
<idno type="wicri:Area/Istex/Curation">000107</idno>
<idno type="wicri:Area/Istex/Checkpoint">002006</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002006</idno>
<idno type="wicri:doubleKey">0031-8655:1988:Manyak M:protection:against:dihematoporphyrin</idno>
<idno type="wicri:Area/Main/Merge">003315</idno>
<idno type="wicri:Area/Main/Curation">003244</idno>
<idno type="wicri:Area/Main/Exploration">003244</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">PROTECTION AGAINST DIHEMATOPORPHYRIN ETHER PHOTOSENSITIVITY</title>
<author><name sortKey="Manyak, Michael J" sort="Manyak, Michael J" uniqKey="Manyak M" first="Michael J." last="Manyak">Michael J. Manyak</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Radiation Oncology, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Correspondence address: *To whom correspondence should be addressed at the National Cancer Institute, Radiation Oncology Branch, Experimental Phototherapy Section, Bldg. 10, Room B3‐B69, 9000 Rockville Pike, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Paul D" sort="Smith, Paul D" uniqKey="Smith P" first="Paul D." last="Smith">Paul D. Smith</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biomedical Engineering and Instrumentation Branches, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrington, Frank S" sort="Harrington, Frank S" uniqKey="Harrington F" first="Frank S." last="Harrington">Frank S. Harrington</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Radiation Oncology, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steinberg, Seth M" sort="Steinberg, Seth M" uniqKey="Steinberg S" first="Seth M." last="Steinberg">Seth M. Steinberg</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biostatistics and Data Management Section of the National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Glatstein, Eli" sort="Glatstein, Eli" uniqKey="Glatstein E" first="Eli" last="Glatstein">Eli Glatstein</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Radiation Oncology, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Russo, Angelo" sort="Russo, Angelo" uniqKey="Russo A" first="Angelo" last="Russo">Angelo Russo</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Radiation Oncology, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Correspondence address: *To whom correspondence should be addressed at the National Cancer Institute, Radiation Oncology Branch, Experimental Phototherapy Section, Bldg. 10, Room B3‐B69, 9000 Rockville Pike, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Photochemistry and Photobiology</title>
<title level="j" type="alt">PHOTOCHEMISTRY PHOTOBIOLOGY</title>
<idno type="ISSN">0031-8655</idno>
<idno type="eISSN">1751-1097</idno>
<imprint><biblScope unit="vol">47</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="823">823</biblScope>
<biblScope unit="page" to="830">830</biblScope>
<biblScope unit="page-count">8</biblScope>
<publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="1988-06">1988-06</date>
</imprint>
<idno type="ISSN">0031-8655</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0031-8655</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">AbstractAmelioration of dihematoporphyrin ether (DHE) induced skin photosensitivity by medications either suspected or known to influence porphyrin metabolism or inflammatory response was evaluated in 357 female athymic NCR‐nude mice (308 study animals, 49 controls) in 56 separate study groups. Seventy‐two hours after injection with 25 mg/kg of DHE, the study animals'abdomens were irradiated with 4.125‐4.25 J/cm2 of visible light. Controls were irradiated after receiving either medication, solubilizing agent, or no injection. The abdominal surface burns were examined daily and graded as extensive, partial, or no burn. Statistical comparison was made between irradiated mice injected with DHE only and irradiated mice injected with DHE and medication. Injection of medications which influenced metabolism (hydroxychloroquine, hydrochlorothiazide) produced fewer extensive (P < 0.01) but greater frequencies of partial burns than DHE controls. Medications which block histamine effect (cimetidine and/or hydroxyzine) resulted in fewer extensive (P < 0.03) and roughly equal frequencies of partial burns compared with DHE controls. Steroids (dexamethasone, methylpred‐nisolone, triamcinolone) which interfere with inflammatory response resulted in similar extensive and partial burn levels. Control animals receiving only medication, solubilizing agent, or no injection had no photosensitivity and consequently showed no burns. The results from this study suggest that inhibition of histamine effect and, to a lesser extent, increased activity of porphyrin catabolic pathways may decrease skin photosensitivity associated with DHE administration.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Manyak, Michael J" sort="Manyak, Michael J" uniqKey="Manyak M" first="Michael J." last="Manyak">Michael J. Manyak</name>
</region>
<name sortKey="Glatstein, Eli" sort="Glatstein, Eli" uniqKey="Glatstein E" first="Eli" last="Glatstein">Eli Glatstein</name>
<name sortKey="Harrington, Frank S" sort="Harrington, Frank S" uniqKey="Harrington F" first="Frank S." last="Harrington">Frank S. Harrington</name>
<name sortKey="Manyak, Michael J" sort="Manyak, Michael J" uniqKey="Manyak M" first="Michael J." last="Manyak">Michael J. Manyak</name>
<name sortKey="Russo, Angelo" sort="Russo, Angelo" uniqKey="Russo A" first="Angelo" last="Russo">Angelo Russo</name>
<name sortKey="Russo, Angelo" sort="Russo, Angelo" uniqKey="Russo A" first="Angelo" last="Russo">Angelo Russo</name>
<name sortKey="Smith, Paul D" sort="Smith, Paul D" uniqKey="Smith P" first="Paul D." last="Smith">Paul D. Smith</name>
<name sortKey="Steinberg, Seth M" sort="Steinberg, Seth M" uniqKey="Steinberg S" first="Seth M." last="Steinberg">Seth M. Steinberg</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003244 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003244 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:3F2B3C57C23C404530C3C9459B88A875163C0931 |texte= PROTECTION AGAINST DIHEMATOPORPHYRIN ETHER PHOTOSENSITIVITY }}
This area was generated with Dilib version V0.6.33. |